Unlike Thalassemia Major, Thalassemia Minor has only one defective beta globin gene People with thalassemia minor or trait usually do not need blood transfusions because they either do not have anemia or have only a mild anemia. The homozygous form of beta thalassemia (thalassemia major) is not immediately lethal because there is some production of Hb F, which does not contain beta chains. If the synthesis from both genes … Thalassemia is a genetic blood disorder that impacts the ability of the blood to get oxygen to the body’s organs. Beta thalassemia is a recessive genetic disorder of hemoglobin structure. Beta thalassemia is a blood disorder that reduces the production of hemoglobin. β thalassemia minor is caused by a β/β o or β/β + genotype. 1,5% global population are heterozygotes for this disease. Many times people with thalassemia are prescribed a supplemental B vitamin, known as folic acid, to help treat anemia. This is sometimes referred to as "the rule of threes." Beta thalassemia most often occurs in people of Mediterranean origin. Different forms of beta thalassemia occur if one or more of these genes are altered: If one gene is altered—a person is a “silent” carrier of beta thalassemia. 1,3in beta-thalassemia minor 1,3. usually clinically asymptomatic, but may have mild anemia If you have mild anemia, folic acid supplements can help. If one parent has beta thalassemia trait and the other parent has normal hemoglobin A, there is a 50 percent (1 in 2) chance with each pregnancy of having a child with beta thalassemia trait . Beta thalassemia trait is also known as beta thalassemia minor. Beta-thalassemia results of a default in the hemoglobin beta-chain synthesis. An inherited blood disorder (usually clinically asymptomatic) resulting from the heterozygous inheritance of beta-thalassemia mutation or deletion in the beta-globin (HBB) gene on chromosome 11. Only one of the two β globin alleles contains a mutation, so β chain production is not terribly compromised and patients may be relatively asymptomatic. Hemoglobin is the iron-containing protein in red blood cells that carries oxygen to cells throughout the body. Beta thalassemia major, the homozygous state when the gene is inherited from both parents, is characterized by hemolytic anemia (i.e., early breakdown of red blood cells). This rule will usually not apply in cases of beta thalassemia, particularly beta thalassemia minor where the RBCs are not normochromic and are microcytic, and where there is a disproportionate number of … Learn about the signs, how it’s diagnosed & treated. Beta Thalassemia Minor (or Thalassemia Minor), a rare genetic blood disorder, is a defect in the synthesis of beta chains of hemoglobin (a protein that carries oxygen to the tissues). The one gene defect, beta thalassemia trait (minor), is asymptomatic and results in microcytosis and mild anemia. 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